Leptin levels increase during flutamide therapy in women with polycystic ovary syndrome


Sahin I., SERTER R., Karakurt F., Demirbas B., Guler S., Culha C., ...Daha Fazla

HORMONE RESEARCH, cilt.60, ss.232-236, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1159/000074037
  • Dergi Adı: HORMONE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.232-236
  • Anahtar Kelimeler: flutamide, leptin, polycystic ovary syndrome, RECEPTOR, OBESE, TESTOSTERONE, HIRSUTISM, NONOBESE, GENE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Aim: To evaluate the serum leptin levels and the effects of flutamide treatment on the leptin levels in women with polycystic ovary syndrome (PCOS). Methods: 20 women with PCOS and 20 controls were enrolled in the study. Leptin levels and leptin response to an oral glucose tolerance test were assessed in both groups before and after a 4-week flutamide therapy period. Results: The leptin levels were similar in both groups at baseline. In the PCOS group, leptin levels and area under curve for leptin levels increased significantly after flutamide treatment. Conclusions: Women with PCOS had similar leptin levels to those of controls with similar age and body mass index. Flutamide treatment led to increased leptin levels and leptin responses to oral glucose tolerance tests in PCOS patients. Further studies are needed to gain insights into the clinical consequences of these effects of flutamide. Copyright (C) 2003 S. Karger AG, Basel.