; The Role of the Local Bone Marrow Renin-Angiotensin System in Multiple Myeloma


Sakai B., SAYİTOĞLU M., İSTEMİHAN Z., KARAN M. A. , ERTEN S. N. , Dogan O., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.36, no.3, pp.178-185, 2019 (Journal Indexed in SCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.4274/tjh.galenos.2019.2018.0420
  • Title of Journal : TURKISH JOURNAL OF HEMATOLOGY
  • Page Numbers: pp.178-185
  • Keywords: Multiple myeloma, Renin-angiotensin system, Angiotensin type 1a receptor, HEMATOPOIETIC STEM-CELLS, TUMOR ANGIOGENESIS, LEUKEMIA, PROGRESSION, RECEPTORS, REGULATOR, SPECTRUM, PATHWAY, GROWTH, RISK

Abstract

Objective: Angiotensin II promotes growth and angiogenesis via type 1 receptors (AGTR1) in certain tumors. In this study, we examine the bone marrow AGTR1 expression in multiple myeloma (MM) and its relationship with the regulation of angiogenesis and prognostic factors.