Role of urinary zinc and copper on calcium oxalate stone formation

Ozgurtas T., Yakut G., Gulec M., SERDAR M. A. , Kutluay T.

UROLOGIA INTERNATIONALIS, vol.72, no.3, pp.233-236, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1159/000077122
  • Page Numbers: pp.233-236


Introduction: It is considered that many factors may play a role in urolithiasis. Experimental and clinical studies have shown that zinc has an inhibitory effect on urolithiasis. Materials and Methods: In this study, urinary zinc and copper were measured in 27 healthy controls and 30 calcium oxalate stone formers. Results: Urinary zinc excretion was significantly higher (p < 0.001) in stone formers than healthy controls ( 2,575 B 274 and 960 +/- 80 mg/day, respectively). There was no significant difference in urinary copper excretion between healthy controls and stone formers (32.3 +/- 3.5 and 33.3 +/- 3.2 mug/day, respectively). Conclusions: According to our results, the potent inhibitory effect of urinary zinc excretion on urolithiasis could be reviewed. Copyright (C) 2004 S. Karger AG, Basel.