Expression of IFITM1 in chronic myeloid leukemia patients


Akyerli C. , Beksac M., Holko M., Frevel M., Dalva K., Ozbek U. , ...More

Leukemia Research, vol.29, no.3, pp.283-286, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1016/j.leukres.2004.07.007
  • Title of Journal : Leukemia Research
  • Page Numbers: pp.283-286

Abstract

We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival. (C) 2004 Elsevier Ltd. All rights reserved.