The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis


Cardone M., Kandilci A., Carella C., Nilsson J., Brennan J., Sirma S., ...Daha Fazla

MOLECULAR AND CELLULAR BIOLOGY, cilt.25, ss.2395-2405, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 25 Konu: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1128/mcb.25.6.2395-2405.2005
  • Dergi Adı: MOLECULAR AND CELLULAR BIOLOGY
  • Sayfa Sayıları: ss.2395-2405

Özet

The human ETS family gene TEL2/ETV7 is highly homologous to TELI/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and WC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.