The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis


Cardone M., Kandilci A., Carella C., Nilsson J., Brennan J., Sirma S., ...More

MOLECULAR AND CELLULAR BIOLOGY, vol.25, no.6, pp.2395-2405, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1128/mcb.25.6.2395-2405.2005
  • Title of Journal : MOLECULAR AND CELLULAR BIOLOGY
  • Page Numbers: pp.2395-2405

Abstract

The human ETS family gene TEL2/ETV7 is highly homologous to TELI/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and WC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.