Prepubertal Unilateral Gynecomastia: Report of 2 Cases

Demirbilek H., Bacak G., Baran R. T., Avci Y., Baran A., Keles A., ...More

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.6, no.4, pp.250-253, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.4274/jcrpe.1477
  • Journal Name: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.250-253
  • Keywords: Gynecomastia, pubertal, prepubertal, unilateral, GIANT-CELL FIBROBLASTOMA, DOMINANT TRANSMISSION, EXCESS, BREAST
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Prepubertal unilateral gynecomastia is an extremely rare condition. At present, its etiology and management strategy are not well known. Two unrelated prepubertal boys of ages 8 and 9 who presented with complaints of unilateral enlargement of breast tissue are reported. Physical examination, biochemical, hormonal and oncologic work-up findings were normal. Both patients were treated with peripheral liposuction successfully. Histopathological and immunohistochemical examinations showed benign fibroglandular gynecomastia and intensive (3+) estrogen receptor expression in 100% of periductal epithelial cells. Although an extremely rare and generally benign condition, patients with prepubertal unilateral gynecomastia should have a full endocrine and oncologic work-up.