Oral tadalafil reduces intra-abdominal adhesion reformation in rats.

Kutuk M. S. , ÖZGÜN M. T. , Batukan C. , ÖZÇELİK B., Basbug M., ÖZTÜRK A.

Human reproduction (Oxford, England), vol.27, no.3, pp.733-7, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1093/humrep/der439
  • Title of Journal : Human reproduction (Oxford, England)
  • Page Numbers: pp.733-7


Currently, there is no ideal agent to prevent adhesion formation. We have shown that sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, reduces post-operative adhesion formation by vasodilatation and increases fibrinolytic activity. Here, we evaluated whether tadalafil, a long-acting PDE-5 inhibitor, decreases post-operative adhesion reformation in rats.