Oral tadalafil reduces intra-abdominal adhesion reformation in rats.


Kutuk M. S. , ÖZGÜN M. T. , Batukan C. , ÖZÇELİK B., Basbug M., ÖZTÜRK A.

Human reproduction (Oxford, England), cilt.27, ss.733-7, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 27 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1093/humrep/der439
  • Dergi Adı: Human reproduction (Oxford, England)
  • Sayfa Sayıları: ss.733-7

Özet

Currently, there is no ideal agent to prevent adhesion formation. We have shown that sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, reduces post-operative adhesion formation by vasodilatation and increases fibrinolytic activity. Here, we evaluated whether tadalafil, a long-acting PDE-5 inhibitor, decreases post-operative adhesion reformation in rats.