Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis

Benitz, Simone; Straub, Tobias; Mahajan, Ujjwal; Mutter, Jurik; Czemmel, Stefan; Unruh, Tatjana; Wingerath, Britta; Deubler, Sabrina; Fahr, Lisa; Cheng, Tao; Nahnsen, Sven; Bruns, Philipp; Kong, Bo; Raulefs, Susanne; Ceyhan, GÜRALP; Mayerle, Julia; Steiger, Katja; Esposito, Irene; Kleeff, Joerg; Michalski, Christoph; Regel, Ivonne

doi:10.1136/gutjnl-2018-317208

Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis

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Benitz S., Straub T., Mahajan U. M., Mutter J., Czemmel S., Unruh T., ...More

GUT, vol.68, no.11, pp.2007-2018, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 68 Issue: 11
Publication Date: 2019
Doi Number: 10.1136/gutjnl-2018-317208
Journal Name: GUT
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2007-2018
Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background and aims Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling cell homeostasis are extensively downregulated during cancer development; however, the underlying mechanisms are poorly understood. Now, we devised a novel in vitro strategy to determine genome-wide dynamics in the epigenetic landscape in pancreatic carcinogenesis.