Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis

Benitz S., Straub T., Mahajan U. M. , Mutter J., Czemmel S., Unruh T., ...More

GUT, vol.68, no.11, pp.2007-2018, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 11
  • Publication Date: 2019
  • Doi Number: 10.1136/gutjnl-2018-317208
  • Title of Journal : GUT
  • Page Numbers: pp.2007-2018


Background and aims Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling cell homeostasis are extensively downregulated during cancer development; however, the underlying mechanisms are poorly understood. Now, we devised a novel in vitro strategy to determine genome-wide dynamics in the epigenetic landscape in pancreatic carcinogenesis.