Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis
GUT, cilt.68, sa.11, ss.2007-2018, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 11
- Basım Tarihi: 2019
- Doi Numarası: 10.1136/gutjnl-2018-317208
- Dergi Adı: GUT
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2007-2018
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
Background and aims Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling cell homeostasis are extensively downregulated during cancer development; however, the underlying mechanisms are poorly understood. Now, we devised a novel in vitro strategy to determine genome-wide dynamics in the epigenetic landscape in pancreatic carcinogenesis.