Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis


Benitz S., Straub T., Mahajan U. M. , Mutter J., Czemmel S., Unruh T., ...Daha Fazla

GUT, cilt.68, sa.11, ss.2007-2018, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 68 Konu: 11
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1136/gutjnl-2018-317208
  • Dergi Adı: GUT
  • Sayfa Sayıları: ss.2007-2018

Özet

Background and aims Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling cell homeostasis are extensively downregulated during cancer development; however, the underlying mechanisms are poorly understood. Now, we devised a novel in vitro strategy to determine genome-wide dynamics in the epigenetic landscape in pancreatic carcinogenesis.