Background: Wound healing follows a predictable course of overlapping phases, which involve cellular and biochemical events: (a) hemostasis and inflammation, (b) proliferation and (c) maturation and remodeling. Platelet Rich Plasma (PRP) is obtained by the blood from the patient being concentrated using different techniques. In the light of this basic information, platelet rich plasma (PRP) is used in many areas, especially orthopedic, oral and maxillofacial, dental, ophthalmic, plastic and reconstructive surgeries. In this experimental study performed on rats, the effects of PRP in wound healing were investigated. Methods: The study included 24 male Wistar Albino rats. The animals were divided into three groups, each consisting of 8 animals. Any treatment was not given for defects created in Group 1 and it formed the control group. PRP was applied topically on lesion in Group 2. PRP was injected on the lesion in Group 3. Results: Angiogenesis increased with the topical application, and the tissue durability increased with the intralesional injection. Conclusion: We can state that PRP had positive effects on the wound healing, the angiogenesis increased with the topical application, and the tissue durability increased with the intralesional injection. We believe that there is a need for new publications on this subject.