Cerebrovascular Reactivity of Migraine Patients to Breath hold and Hyper ventilation Challenge assessed by fNIRS: Preliminary Findings

Yorgancıgil E., Yukselen G., Erdoğan S. B., Akın A.

The ISOTT 2025 (International Society on Oxygen Transport to Tissue) Annual Meeting, Thessaloniki, Yunanistan, 24 - 28 Ağustos 2025, ss.1-3, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Thessaloniki
  • Basıldığı Ülke: Yunanistan
  • Sayfa Sayıları: ss.1-3
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Cerebrovascular reactivity (CVR) represents the compensatory capacity of cerebral blood

vessels to constrict or dilate under different physiological conditions [1]. It is often

considered to reflect the responsiveness of cerebral microvasculature networks. Migraine

is considered as a neurovascular coupling (NVC) disorder where CVR is malfunctioning

[2]. In this ongoing study, we investigated the differences in CVR of healthy controls (13

subjects, 8 females, mean age: 25.9±2.7) and migraine patients (12 subjects, 10 females,

mean age: 33.5±9.3) during a breath hold (BH) and hyper ventilation (HV) challenge by

using a 22 channel NIRSport system with optodes placed over the prefrontal cortex. Data

were sampled at 7.8 Hz and converted to HB, HBO values. HB and HBO data of each

channel were detrended with a 2 nd order polynomial fit to remove the baselines, cleaned

from severe motion artifacts by an outlier elimination method, subjected to wavelet

denoising at the 3 rd level, and decimated 4 times. A 4 th order Butterworth low pass filter

was employed with a cut-off frequency at 0.5 Hz. A general linear model approach was

employed to obtain the scaled model regressors, which were then used to reconstruct the

fitted model response for each channel. The maximum (MAX) and area under the curve

(AUC) values were computed for channel-specific HB and HBO signals. During the BH

task, migraine patients

showed significantly lower

MAX values and delayed

peak latencies when

compared to healthy

controls. Similarly, during

the HV task, HBO responses of migraine patients demonstrated reduced amplitudes,

negative AUC values, and altered peak latencies when compared to those observed in

healthy controls. Overall, our initial results confirm that CVR in migraine patients are

suppressed and there is a deficiency of blood flow supply leading to an impaired

neurovascular coupling.