Size distribution of circulating cell-free DNA in sera of breast cancer patients in the course of adjuvant chemotherapy


GEZER U., Eralp Y., YÖRÜKER E. E. , Akisik E. Z. , Saip P., Topuz E., ...More

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.46, no.3, pp.311-317, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1515/cclm.2008.080
  • Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.311-317
  • Keywords: adjuvant therapy, breast cancer, cell-free DNA, serum, size distribution, GENE PROMOTER HYPERMETHYLATION, REAL-TIME PCR, NUCLEIC-ACIDS, PROSTATE-CANCER, TUMOR DNA, PLASMA, APOPTOSIS, DOXORUBICIN, INTEGRITY, THERAPY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: The integrity of circulating cell-free DNA (cf-DNA) in serum or plasma appears to be of diagnostic and prognostic value in cancer. Here, we investigated the dynamics of serum DNA levels and the size distribution of cf-DNA during adjuvant chemotherapy of patients with breast cancer (n =73).