Size distribution of circulating cell-free DNA in sera of breast cancer patients in the course of adjuvant chemotherapy

GEZER U., Eralp Y., YÖRÜKER E. E., Akisik E. Z., Saip P., Topuz E., ...More

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.46, no.3, pp.311-317, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1515/cclm.2008.080
  • Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.311-317
  • Keywords: adjuvant therapy, breast cancer, cell-free DNA, serum, size distribution, GENE PROMOTER HYPERMETHYLATION, REAL-TIME PCR, NUCLEIC-ACIDS, PROSTATE-CANCER, TUMOR DNA, PLASMA, APOPTOSIS, DOXORUBICIN, INTEGRITY, THERAPY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: The integrity of circulating cell-free DNA (cf-DNA) in serum or plasma appears to be of diagnostic and prognostic value in cancer. Here, we investigated the dynamics of serum DNA levels and the size distribution of cf-DNA during adjuvant chemotherapy of patients with breast cancer (n =73).