Prenatal ultrasound findings and a new ultrasonographic sign of epidermolysis bullosa with congenital pyloric atresia: a report of three cases


Dural O., Acar D. K. , Ekiz A., Aslan H., Polat I., Yildirim G., ...Daha Fazla

JOURNAL OF MEDICAL ULTRASONICS, cilt.41, ss.495-498, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 41 Konu: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s10396-014-0532-1
  • Dergi Adı: JOURNAL OF MEDICAL ULTRASONICS
  • Sayfa Sayıları: ss.495-498

Özet

Epidermolysis bullosa with pyloric atresia (EBPA) is a rare autosomal recessive disease that is characterized by fragility of the skin and mucous membranes. The course of EB-PA is usually severe and often lethal in the neonatal period. In most cases, prenatal diagnosis of this syndrome is considered in pregnancies at risk for recurrence. EB-PA can be described during pregnancy with sonographic signs such as polyhydramnios with a dilated stomach, the "snowflake sign'', which are echogenic particles in the amniotic fluid, and several other anomalies. In this report, we present three cases of EB-PA suggested by the results of prenatal sonography, and describe a new ultrasonographic sign, i.e., complete chorioamniotic membrane separation, which can be helpful for the diagnosis. The prenatal diagnoses were confirmed postnatally. Two of the three cases had no family history, and one of these two cases was the product of a non-consanguineous couple.