Therapeutic Plasma Exchange in an Uncommon Disease: Stiff-Person Syndrome: Case Report

Hergünsel O., Altun D., Çukurova Z., Eren G., Yayla V.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.32, no.6, pp.1762-1765, 2012 (SCI-Expanded) identifier identifier


Stiff-Person syndrome (SPS) is a rare and disabling disorder characterized by continuous motor unit activity causing severe rigidity and episodic spasms in axial and limb muscles. It deteriorates the quality of life and causes a serious burden in the patient's life. It is frequently associated with other autoimmune diseases such as diabetes mellitus. Treatment with intravenous immunoglobulin, anti-anxiety drugs, muscle relaxants, anti-convulsants will improve symptoms, but will not cure the disorder. Therapeutic plasma exchange is an alternative treatment for the patients resistant to other treatment options. Here, we report a patient with SPS treated in intensive care unit and underwent therapeutic plasma exchange.