Akademik Veri Yönetim Sistemi
YENI SYMPOSIUM : PSIKIYATRI, NÖROLOJI VE DAVRANIS BILIMLERI DERGISI, cilt.53, sa.2, ss.47-49, 2015 (Scopus)
It is reported that between 20% and 25% of
patients have schizophrenia that is resistant to treatment. The treatment resistance in schizophrenia is defined by many authorities. One of the generally accepted
definitions is inadequate response despite treatment
with different atypical antipsychotics, two or three times at least four-six weeks; the other acceptable one is although the use of two different typical or atypical
antipsychotics in monotherapy during four-six weeks,
inadequate treatment response is obtained. Duratian
of hospitalization in treatment resistant cases is longer.
In addition, when considering all the expenses and loss
of functions, the cost of resistant cases to society is higher. 60 years old, women patient. She was hospitalized from emergency department where she came with
his son, because of denial of treatment and homicidal
intent. It is learned that age of onset was 24, disease
began in a postpartum period, she was diagnosed with
schizophrenia and she had 60 hospitalizations. Although clozapine, haloperidol, amisulpiride, risperidone,
olanzapine, aripiprazole, quetiapine, chlorpromazine,
sulpiride, zuclopenthixol, fluphenazine, lithium and
valproate were used adequate doses and time; a total
of 342 ECT sessions were administered; response or
partial response was achieved, she had not achieved
long-term functioning and well-being. In the most recent admission, she had significant improvement with
clozapine 275 mg/day and valproat 1000 mg/day. Despite all treatment efforts, schizophrenic patient with
excessive admissions and frequent recurrences is discussed.