Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene increases the risk of developing Graves' disease


Dogru-Abbasoglu S., Vural P., Baki M., Ozderya A., Karadag B. , Uysal M.

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.20, ss.366-369, 2014 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 20 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.intimp.2014.03.019
  • Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Sayfa Sayısı: ss.366-369

Özet

Background: Graves' disease (GD) arises due to complex interactions between genetic and environmental factors. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, thyroid follicular cell hyperplasia, and production of autoantibody in the thyroid gland of patients with GD.