Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene increases the risk of developing Graves' disease

Dogru-Abbasoglu S., Vural P., Baki M., Ozderya A., Karadag B. , Uysal M.

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.20, sa.2, ss.366-369, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.intimp.2014.03.019
  • Sayfa Sayıları: ss.366-369


Background: Graves' disease (GD) arises due to complex interactions between genetic and environmental factors. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, thyroid follicular cell hyperplasia, and production of autoantibody in the thyroid gland of patients with GD.