Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene increases the risk of developing Graves' disease


Dogru-Abbasoglu S., Vural P., Baki M., Ozderya A., Karadag B. , Uysal M.

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.20, no.2, pp.366-369, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1016/j.intimp.2014.03.019
  • Title of Journal : INTERNATIONAL IMMUNOPHARMACOLOGY
  • Page Numbers: pp.366-369

Abstract

Background: Graves' disease (GD) arises due to complex interactions between genetic and environmental factors. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, thyroid follicular cell hyperplasia, and production of autoantibody in the thyroid gland of patients with GD.