An unusual combination of relapsing and cholestatic hepatitis A in childhood

Ertekin V. , Selimoglu M., Orbak Z.

YONSEI MEDICAL JOURNAL, vol.44, no.5, pp.939-942, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2003
  • Doi Number: 10.3349/ymj.2003.44.5.939
  • Title of Journal : YONSEI MEDICAL JOURNAL
  • Page Numbers: pp.939-942


Clinical variants of hepatitis A include the prolonged, relapsing and cholestatic forms. Here, the first childhood case of hepatitis A, with a combination of the relapsing and cholestatic forms is presented, a 14-year old boy. In the first phase of the illness, while the AST and ALT levels were declined, th total and direct bilirubin and GGT were increased. The patient was thought to have the cholestatic form of hepatitis A. Du to intense pruritus and high bilirunbin levels, ursodeoxycholic acid (UDCA) therapy was started. On the 17(th) day, the decreased AST and ALT levels began to increase, reaching levels as high as 484 U/L and 862 U/L, respectively. The UDCA treatment was stopped on the 64(th) day. On the 164(th) day, all his laboratory parameters were within normal limits, but the anti-HAV IgM was still positive.