Enteral granulocyte colony-stimulating factor for the treatment of mild (stage I) necrotizing enterocolitis: a placebo-controlled pilot study


Canpolat F. E. , Yurdakok M., Korkmaz A. , Yigit S., Tekinalp G.

JOURNAL OF PEDIATRIC SURGERY, cilt.41, ss.1134-1138, 2006 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 41 Konu: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jpedsurg.2006.02.003
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Sayfa Sayısı: ss.1134-1138

Özet

Background/Purpose: The presence of granulocyte colony-stimulating factor (G-CSF) in human milk and the expression of G-CSF receptors on intestinal villous enterocytes of neonates suggest that G-CSF has a role in the development and integrity of the gastrointestinal tract. We hypothesized that enteral recombinant human G-CSF (rhG-CSF) given to preterm infants with necrotizing enterocolitis (NEC) in the earlier stages could protect against disease progression and complications.