Enteral granulocyte colony-stimulating factor for the treatment of mild (stage I) necrotizing enterocolitis: a placebo-controlled pilot study

Canpolat F. E., Yurdakok M., Korkmaz A., Yigit S., Tekinalp G.

JOURNAL OF PEDIATRIC SURGERY, vol.41, no.6, pp.1134-1138, 2006 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jpedsurg.2006.02.003
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1134-1138
  • Keywords: G-CSF, necrotizing enterocolitis, prematurity, GASTROINTESTINAL-TRACT, NITRIC-OXIDE, HUMAN FETUS, RAT MODEL, ERYTHROPOIETIN, INFANTS, RECEPTOR, PATHOGENESIS, CYTOKINES, WEIGHT
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background/Purpose: The presence of granulocyte colony-stimulating factor (G-CSF) in human milk and the expression of G-CSF receptors on intestinal villous enterocytes of neonates suggest that G-CSF has a role in the development and integrity of the gastrointestinal tract. We hypothesized that enteral recombinant human G-CSF (rhG-CSF) given to preterm infants with necrotizing enterocolitis (NEC) in the earlier stages could protect against disease progression and complications.