The importance of histological patterns on PD-L1 staining heterogeneity: Should we use pattern-based approach for selecting tumor samples for PD-L1 testing in lung adenocarcinomas?

Bulutay P., Firat P., Zeren H. , Erus S., Tanju S., Dilege S.

Turkish journal of medical sciences, vol.51, no.1, pp.204-213, 2021 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2004-61
  • Title of Journal : Turkish journal of medical sciences
  • Page Numbers: pp.204-213


Background/aim: Programmed death ligand-1 (PD-L1) is a predictive marker for immunotherapeutic agents. However, heterogeneous staining of PD-L1 can cause false-negative results. The aim of this study is to evaluate the importance of histological patterns on PD-L1 staining heterogeneity in lung adenocarcinomas (LAC).