Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization


Ekineker G., Nguyen C., Bayir S., Dominguez Gil S., Isci U., Daurat M., ...More

CHEMICAL COMMUNICATIONS, vol.55, no.77, pp.11619-11622, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 77
  • Publication Date: 2019
  • Doi Number: 10.1039/c9cc05703j
  • Title of Journal : CHEMICAL COMMUNICATIONS
  • Page Numbers: pp.11619-11622

Abstract

Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.