Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization


Ekineker G., Nguyen C., Bayir S., Dominguez Gil S., Isci U., Daurat M., ...Daha Fazla

CHEMICAL COMMUNICATIONS, cilt.55, ss.11619-11622, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 55 Konu: 77
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1039/c9cc05703j
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Sayfa Sayıları: ss.11619-11622

Özet

Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.