SET oncogene is upregulated in pediatric acute lymphoblastic leukemia

SIRMA EKMEKCİ, Sema; Ekmekci, Cumhur; Kandilci, Ayten; GÜLEÇ, Çağrı; Akbiyik, Meral; EMRENCE, Zeliha; ABACI, Neslihan; KARAKAŞ, Zeynep; Agaoglu, Leyla; ÜNÜVAR, Ayşegül; Anak, Sema; Devecioglu, Omer; Ustek, Duran; Grosveld, Gerard; ÖZBEK, UĞUR

doi:10.1177/030089161209800212

SET oncogene is upregulated in pediatric acute lymphoblastic leukemia

SIRMA EKMEKCİ S., Ekmekci C. G., Kandilci A., GÜLEÇ Ç., Akbiyik M., EMRENCE Z., ...Daha Fazla

TUMORI JOURNAL, cilt.98, sa.2, ss.252-256, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 98 Sayı: 2
Basım Tarihi: 2012
Doi Numarası: 10.1177/030089161209800212
Dergi Adı: TUMORI JOURNAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.252-256
Anahtar Kelimeler: acute lymphoblastic leukemia, pediatric ALL, SET, SET overexpression, ACUTE MYELOID-LEUKEMIA, TRANSLOCATION BREAKPOINT, SET-NUP214 FUSION, PROTEIN SET, EXPRESSION, INHIBITOR
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Aims and background. The SET gene is a target of chromosomal translocations in acute leukemia and encodes a widely expressed multifunctional phosphoprotein. It has been shown that SET is upregulated in BCR-ABL1-positive cell lines, patient-derived chronic myeloid leukemia CD34-positive cells, and some solid tumors.