SET oncogene is upregulated in pediatric acute lymphoblastic leukemia

SIRMA EKMEKCİ S., Ekmekci C. G., Kandilci A., GÜLEÇ Ç., Akbiyik M., EMRENCE Z., ...Daha Fazla

TUMORI JOURNAL, cilt.98, sa.2, ss.252-256, 2012 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/030089161209800212
  • Dergi Adı: TUMORI JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.252-256
  • Anahtar Kelimeler: acute lymphoblastic leukemia, pediatric ALL, SET, SET overexpression, ACUTE MYELOID-LEUKEMIA, TRANSLOCATION BREAKPOINT, SET-NUP214 FUSION, PROTEIN SET, EXPRESSION, INHIBITOR
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Aims and background. The SET gene is a target of chromosomal translocations in acute leukemia and encodes a widely expressed multifunctional phosphoprotein. It has been shown that SET is upregulated in BCR-ABL1-positive cell lines, patient-derived chronic myeloid leukemia CD34-positive cells, and some solid tumors.