Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy


Kucukkaya B., GÜLHAN R., YÜKSEL M., Onat F., YALÇIN A. S.

BRAIN RESEARCH, vol.788, pp.133-136, 1998 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 788
  • Publication Date: 1998
  • Doi Number: 10.1016/s0006-8993(97)01544-8
  • Journal Name: BRAIN RESEARCH
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.133-136
  • Keywords: chemiluminescence, MK-801, iron-induced epilepsy, oxidative changes, EPILEPTIFORM DISCHARGES, LIPID-PEROXIDATION, PHENCYCLIDINE, BRAIN, ANTAGONISTS, INJECTION, RADICALS, STRESS

Abstract

We have used chemiluminescence measurements to examine the relationship between free radical formation and excitotoxicity in a post-traumatic epilepsy model. For this purpose, seven days after injecting iron in rat brain cortices, we measured luminol-and lucigenin-enhanced chemiluminescence in different brain regions (ipsilateral cortex, contralateral cortex, hypothalamus and hippocampus), In all brain regions (except contralateral cortices) both luminol- and lucigenin-enhanced chemiluminescence were increased in iron-injected group compared to saline-injected control group. These increases returned to control values in iron-injected rats pretreated with MK-801. Our results suggest that both free radicals and excitatory amino acids play important roles in the development of post-traumatic epilepsy and that MK-801 has protective effects against iron-induced chemiluminescence formation. (C) 1998 Elsevier Science B.V.