Evaluation of the Efficacy of SiIdenafil Citrate Following Severe Head Trauma in an Experimental Rat Model

Kilicarslan B., Kilicarslan E., KIZMAZOĞLU C., Aydin H. E., Kaya I., Danyeli A., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.30, sa.4, ss.501-506, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5137/1019-5149.jtn.23864-18.3
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.501-506
  • Anahtar Kelimeler: Sildenafil citrate, Mannitol, Severe head trauma, Rat, DIFFUSE BRAIN-INJURY, CEREBRAL VASOSPASM, FUNCTIONAL RECOVERY, CYCLIC-GMP, SILDENAFIL, TERM, INHIBITION, MANNITOL, HYPOPERFUSION, TADALAFIL
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

AIM: To investigate the acute effects of sildenafil citrate in an experimental model of severe head trauma, and to compare it with the efficacy of mannitol, which is an osmotically active agent frequently used in clinical treatment of traumatic brain injury (TBI).