Thrombin activatable fibrinolysis inhibitor activity (TAFIa) levels in neonates with meconium-stained amniotic fluid

Gursoy T., Tekinalp G., YİĞİT Ş., Kirazli S., Korkmaz A., Gurgey A.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.21, sa.2, ss.123-128, 2008 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/14767050801891135
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-128
  • Anahtar Kelimeler: TAFIa, neonate, hypoxia, inflammation, meconium-stained amniotic fluid, ASPIRATION SYNDROME, INFLAMMATORY RESPONSE, INTRAPARTUM, COMPLEMENT, EXPRESSION, SERUM
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective.Meconium-stained amniotic fluid (MSAF) is thought to be a sign of fetal hypoxia, which causes activation of coagulation and inhibition of fibrinolysis. Inflammation is also seen in MSAF. On the other hand, thrombin activatable fibrinolysis inhibitor (TAFI) is an inhibitor of fibrinolysis and a regulator of vascular inflammation. For this reason, in this study we aimed to evaluate the relation between hypoxia, fibrinolysis, and inflammation by determining the levels of TAFI activity (TAFIa) in MSAF where inflammation was also thought to have a role in the pathogenesis.