Peroxisome proliferator-activated receptor alpha L162V polymorphism in nonalcoholic steatohepatitis and genotype 1 hepatitis C virus-related liver steatosis


Verdi H., Koytak E., Onder O. , Cinar K., Idilman R., Erden E., ...More

JOURNAL OF INVESTIGATIVE MEDICINE, vol.53, no.7, pp.353-359, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 7
  • Publication Date: 2005
  • Doi Number: 10.2310/6650.2005.53706
  • Title of Journal : JOURNAL OF INVESTIGATIVE MEDICINE
  • Page Numbers: pp.353-359

Abstract

Background: Peroxisome proliferator-activated receptor a (PPAR alpha) plays important roles in lipid metabolism. A recently discovered L162V polymorphism of the PPARa gene is associated with enhanced transcriptional activity. In this study, the frequency of L162V was investigated in nonalcoholic steatohepatitis (NASH) and genotype 1 hepatitis C virus (HCV)-related liver steatosis.