Peroxisome proliferator-activated receptor alpha L162V polymorphism in nonalcoholic steatohepatitis and genotype 1 hepatitis C virus-related liver steatosis


Verdi H., Koytak E., Onder O. , Cinar K., Idilman R., Erden E., ...Daha Fazla

JOURNAL OF INVESTIGATIVE MEDICINE, cilt.53, ss.353-359, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 53 Konu: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.2310/6650.2005.53706
  • Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
  • Sayfa Sayıları: ss.353-359

Özet

Background: Peroxisome proliferator-activated receptor a (PPAR alpha) plays important roles in lipid metabolism. A recently discovered L162V polymorphism of the PPARa gene is associated with enhanced transcriptional activity. In this study, the frequency of L162V was investigated in nonalcoholic steatohepatitis (NASH) and genotype 1 hepatitis C virus (HCV)-related liver steatosis.