Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behcet's disease

VURAL B., Sehitoglu E., Cavus F., Yalcinkaya N., Haytural H., Kucukerden M., ...More

JOURNAL OF NEUROIMMUNOLOGY, vol.263, no.1-2, pp.139-144, 2013 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 263 Issue: 1-2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jneuroim.2013.08.007
  • Journal Name: JOURNAL OF NEUROIMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.139-144
  • Keywords: Behcet's disease, Neuro-Behcet's disease, Anti-neuronal antibody, Mitochondrial carrier homolog 1, Antibody, Autoimmunity, CLINICAL-SIGNIFICANCE, DIAGNOSTIC-CRITERIA, PATHERGY REACTION, SERUM-LEVELS, PROTEIN
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. (C) 2013 Elsevier B.V. All rights reserved.