Generalized papular and sclerodermoid eruption: Scleromyxedema


Serdar Z. A. , Altunay I. K. , Yasar S. P. , Erfan G., Gunes P.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, vol.76, no.5, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.4103/0378-6323.69096
  • Journal Name: INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
  • Journal Indexes: Science Citation Index Expanded

Abstract

Scleromyxedema (SM) is a rare chronic progressive and highly intractable cutaneous disease with unknown etiology, affecting both genders equally between 30 and 50 years. The disease is characterized with mucin deposits in the skin and/or other organs. In fact it is a clinicopathological subset of lichen myxedematosus (LM) according to a new classification. Sclerodermiform plaques and lichenoid papules are characteristic cutaneous lesions. An elevation of IgG lambda (lambda) chain exists in most cases and extracutaneous involvement occurring with variable systemic findings is also detected. Generalized form is quite difficult to treat and may even be fatal. Herein, we present a male patient with typical features of generalized papular and sclerodermoid LM variety and with benign outcome by isotretinoin.