Short-term effects of fluvastatin therapy on plasma interleukin-10 levels in patients with chronic heart failure

Tekin A., Sezgin N. , Katircibasi M. T. , Tekin G., Cokesen Y., Sezgin A. T. , et al.

CORONARY ARTERY DISEASE, cilt.19, ss.513-519, 2008 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 19 Konu: 7
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/mca.0b013e32830d27d2
  • Dergi Adı: CORONARY ARTERY DISEASE
  • Sayfa Sayısı: ss.513-519

Özet

Background Experimental data demonstrated that inflammatory mediators, such as pro-inflammatory and anti-inflammatory cytokines and their receptors might have important role in the development and the progression of heart failure (HF). Statins were shown to downregulate inflammatory cytokines in HE Interleukin (IL)-10 is one of the most important anti-inflammatory cytokines. The effect of statin therapy on plasma IL-10 levels is not known in patients with HE We conducted this study to investigate the effects of fluvastatin therapy on plasma IL-10 cytokine concentration in patients with HE