Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence


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Alaiyan B., Ilyayev N., Stojadinovic A., Izadjoo M., Roistacher M., Pavlov V., ...More

BMC CANCER, vol.13, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2013
  • Doi Number: 10.1186/1471-2407-13-196
  • Journal Name: BMC CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Keywords: Colon cancer, Non-coding RNA, Biomarkers, Adenoma, Carcinoma, CARCINOEMBRYONIC ANTIGEN CEA, GENOME-WIDE ASSOCIATION, COLORECTAL-CANCER, PROGNOSTIC RELEVANCE, GENE-EXPRESSION, DNA METHYLATION, ADENOCARCINOMA, METASTASIS, PROFILES, RECURRENCE
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker. We aimed to define and validate CCAT1 as a CC-specific biomarker, and to study CCAT1 expression across the adenoma- carcinoma sequence of CC tumorigenesis.