Atıf İçin Kopyala
Alaiyan B., Ilyayev N., Stojadinovic A., Izadjoo M., Roistacher M., Pavlov V., ...Daha Fazla
BMC CANCER, cilt.13, 2013 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
13
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Basım Tarihi:
2013
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Doi Numarası:
10.1186/1471-2407-13-196
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Dergi Adı:
BMC CANCER
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Anahtar Kelimeler:
Colon cancer, Non-coding RNA, Biomarkers, Adenoma, Carcinoma, CARCINOEMBRYONIC ANTIGEN CEA, GENOME-WIDE ASSOCIATION, COLORECTAL-CANCER, PROGNOSTIC RELEVANCE, GENE-EXPRESSION, DNA METHYLATION, ADENOCARCINOMA, METASTASIS, PROFILES, RECURRENCE
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Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli:
Hayır
Özet
Background: The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker. We aimed to define and validate CCAT1 as a CC-specific biomarker, and to study CCAT1 expression across the adenoma- carcinoma sequence of CC tumorigenesis.