BMC CANCER, vol.13, 2013 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED)
Colon cancer, Non-coding RNA, Biomarkers, Adenoma, Carcinoma, CARCINOEMBRYONIC ANTIGEN CEA, GENOME-WIDE ASSOCIATION, COLORECTAL-CANCER, PROGNOSTIC RELEVANCE, GENE-EXPRESSION, DNA METHYLATION, ADENOCARCINOMA, METASTASIS, PROFILES, RECURRENCE
Acibadem Mehmet Ali Aydinlar University Affiliated:
Background: The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker. We aimed to define and validate CCAT1 as a CC-specific biomarker, and to study CCAT1 expression across the adenoma- carcinoma sequence of CC tumorigenesis.