Reducing Aortic Barotrauma and Vascular Extracellular Matrix Degradation by Pacemaker-Mediated QRS Widening


Sezer M., Atici A., Coskun I., Cizgici Y., Ozcan A., Umman B., ...More

JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol.9, no.10, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.1161/jaha.119.014804
  • Title of Journal : JOURNAL OF THE AMERICAN HEART ASSOCIATION

Abstract

BACKGROUND: The extent of pressure-related damage might be related to acceleration rate of the applied pressure (peak dP/dt) in the vascular system. In this study, we sought to determine whether dP/dt applied to the aortic wall (aortic dP/dt) and in turn vascular extracellular matrix degradation can be mitigated via modulation of left ventricular (LV) contractility (LV dP/dt) by pacemaker-mediated desynchronization.