Akademik Veri Yönetim Sistemi
Association of Biochemists and Molecular Biologists in B&H Conference, Sarajevo, Bosna-Hersek, 18 - 20 Mayıs 2023, ss.134, (Özet Bildiri)
Pancreatic cancer is a highly aggressive malignancy with a poor prognosis. Neural invasion, the infiltration of tumor cells into the surrounding neural tissue, is a known histopathological feature of pancreatic cancer and is associated with increased tumor aggressiveness and poor patient outcomes.In this study, we aimed to compare gene expression profiles in pancreatic cancer patients with high and low neural invasion scores using bioinformatics tools to gain insight into the molecular mechanisms underlying neural invasion in pancreatic cancer. We used 13 tissue samples from pancreatic cancer
patients undergoing surgical resection and divided them into two groups based on histopathological examination: high neural invasion score (NIS) and low NIS. RNA sequencing was performed from tissue samples. Obtained RNA sequencing data were used to identify differentially expressed genes (DEGs) and for pathway enrichment analysis. Results were analyzed using bioinformatics tools to identify signaling pathways between the high NIS and low NIS groups. As a result of bioinformatic analysis, it was determined that there was a difference in the expression of 1117 genes between the high NIS and low NIS groups. Among them, there are genes that may have a role in cancer metastasis and
neural invasion, such as CDKN2A, TP53I11, MMP8, MMP11, MMP19, SEMA3B, SEMA3D, CXCR5, CCL2, and CCL3. The differentially expressed genes and enriched pathways identified may play important roles in the molecular mechanisms underlying neural invasion and tumor aggressiveness in pancreatic cancer. The findings of this study contribute to a better understanding of the complex molecular landscape of pancreatic cancer. Further functional validation of these differentially expressed genes and pathways could lead to the development of new therapeutic targets for pancreatic cancer patients with high neural invasion scores.