TURKISH THORACIC JOURNAL, cilt.21, sa.1, ss.78-83, 2013 (SCI Expanded İndekslerine Giren Dergi)
Background:The aim of the study is to detect the regional cerebral
oxygen saturation by the help of near infrared spectroscopy
(NIRS) monitorization and to diagnose the hypoxemic or
hyperoxemic episodes for the assessment of the effects of
hypoxia episodes on cerebral perfusion during cardiopulmonary
bypass (CPB) as early as possible.
Methods: The study had been performed in Acıbadem Kadıköy
Hospital during February 2011 and June 2011. Seventy patients
who were admitted with coronary heart disease (CHD) and
scheduled for coronary artery bypass graft (CABG) surgery were
included in the study. The patients were divided into two equal
groups. Thirty five percent of the 35 patients (n=12) were female
in group 1, 50% of 50 patients (n=18) were female in group 2. The
mean age was 60±10 years and 57±11 years in group 1 and group
2, respectively. Group 1 consisted of 35 patients with adjusted
inspired oxygen fraction (FiO2) at 0.35-0.45 during CABG.
Group 2 consisted of 35 patients with adjusted FiO2 at 0.40-
0.50 during surgery. In addition to the standard monitorization,
cerebral cortical oxygen saturation of all patients was monitored
by NIRS. The measurements were done five times during the
course of CABG.
Results: In group 1, hypoxia was detected in five patients
(14%) in at least one of the five measurement periods. In these
patients, FiO2 value increased accompanied by increased ScO2.
In group 2, hyperoxemia was observed in at least one of the
measurement periods in 15 (42.8%) patients. Hypoxia was not
observed in any of the patients in group 2.
Conclusion: It is possible to detect hypoxic periods and to adjust
FiO2 accordingly by means of noninvasive cerebral cortical
oxygen saturation measurement in nonpulsatile flow of CPB