The effect of serum levetiracetam concentrations on therapeutic response and IL1-beta concentration in patients with epilepsy

Gulcebi M. I. , Kendirli T., Turgan Z. A. , Patsalos P. N. , Onat F.

EPILEPSY RESEARCH, vol.148, pp.17-22, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 148
  • Publication Date: 2018
  • Doi Number: 10.1016/j.eplepsyres.2018.09.015
  • Title of Journal : EPILEPSY RESEARCH
  • Page Numbers: pp.17-22


Objective: Assessment of the relevance between serum drug concentration to its therapeutic response is a valid monitoring strategy for the clinical efficacy of antiepileptic drugs (AEDs). Levetiracetam (LEV) is a broad spectrum AED with a possible anti-inflammatory effect. We aimed to determine the relationship between LEV concentrations and its therapeutic response, and the effect of LEV on IL1-beta concentrations in patients with epilepsy.