The effect of serum levetiracetam concentrations on therapeutic response and IL1-beta concentration in patients with epilepsy

Gulcebi M. I., Kendirli T., Turgan Z. A., Patsalos P. N., ONAT F.

EPILEPSY RESEARCH, cilt.148, ss.17-22, 2018 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 148
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.eplepsyres.2018.09.015
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.17-22
  • Anahtar Kelimeler: Antiepileptic drugs, Seizure frequency, Adverse effect, Cytokine, ANTIEPILEPTIC DRUGS, ILAE-COMMISSION, CHILDREN, LAMOTRIGINE, EFFICACY
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective: Assessment of the relevance between serum drug concentration to its therapeutic response is a valid monitoring strategy for the clinical efficacy of antiepileptic drugs (AEDs). Levetiracetam (LEV) is a broad spectrum AED with a possible anti-inflammatory effect. We aimed to determine the relationship between LEV concentrations and its therapeutic response, and the effect of LEV on IL1-beta concentrations in patients with epilepsy.