Polymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population

Koc A., Batar B., Celik Ö., Onaran I., Tasan E., Sultuybek G. K.

IMMUNOBIOLOGY, vol.219, no.7, pp.531-536, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 219 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.1016/j.imbio.2014.03.009
  • Journal Name: IMMUNOBIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.531-536
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Hashimoto thyroiditis (HT) is a chronic inflammatory autoimmune disease of thyroid gland affected by interaction of multiple genes and various cytokines. Variants in the genes coding for the NFKB and IKB proteins can be potentially involved in the development of the inflammatory diseases. NFKB, a key transcription factor of the regulation of immune responses, is interesting candidate for association studies about autoimmune disorder.