Akademik Veri Yönetim Sistemi
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.135, sa.2, ss.183-187, 2007 (SCI-Expanded)
Objective: The purpose of this experimental study was to evaluate the effect of oral sildenafil on postoperative adhesion formation in rats. Study design: Thirty-two Wistar Albino rats were subjected to standardized lesion by cauterization of the uterine horn and abrasion of the adjacent parietal peritoneum. They were randomized to receive sildenafil at a daily dose of 15 mg/kg, 7.5 mg/kg and 3.75 mg/kg or placebo. Sildenafil was administered by gavage I h before the operation and daily for 5 days after the procedure. The extent and severity of adhesions were assessed on the 14th postoperative day. Result(s): The severity but not extent of adhesions in rats given 15 mg/kg sildenafil was significantly less when compared with the other groups (<0.001). Conclusion: Sildenafil diminishes peritoneal adhesion formation in rat. (C) 2006 Elsevier Ireland Ltd. All rights reserved.