The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease


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Atalar F., Gormez S., Caynak B., Akan G., Tanriverdi G., Bilgic-Gazioglu S., ...More

Cardiovascular Diabetology, vol.11, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2012
  • Doi Number: 10.1186/1475-2840-11-115
  • Journal Name: Cardiovascular Diabetology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Keywords: Mediastinal adipose tissue, Glucocorticoid, Inflammation, Coronary artery disease, Stearidonic acid, Cortisol, ECHOCARDIOGRAPHIC EPICARDIAL FAT, DEHYDROGENASE TYPE-1, METABOLIC SYNDROME, CARDIOMETABOLIC RISK, VISCERAL OBESITY, PERICARDIAL FAT, INSULIN-RESISTANCE, MESSENGER-RNA, INFLAMMATION, CORTISOL
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background: Visceral fat deposition and its associated atherogenic complications are mediated by glucocorticoids. Cardiac visceral fat comprises mediastinal adipose tissue (MAT) and epicardial adipose tissue (EAT), and MAT is a potential biomarker of risk for obese patients.