Genetic landscape of pancreatic cancer: a narrative review

Yakar D. O., Bozkirli B. O., CEYHAN G. O.

CHINESE CLINICAL ONCOLOGY, cilt.11, sa.1, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.21037/cco-22-4
  • Dergi Adı: CHINESE CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Anahtar Kelimeler: Pancreatic cancer, genetic, disease biology, RISK, MUTATIONS, SMAD4, PROGRESSION, EXPRESSION, BRCA1, MODEL
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background and Objective: Pancreatic cancer is an aggressive disease with an impaired survival despite improvements in clinical management. Thus, understanding disease biology is of vital importance in order to overcome therapeutic challenges and achieve better prognosis. The purpose of this review is to outline the genetic landscape of pancreatic cancer along with its clinical implications.