Objective: This study thoroughly evaluates the available evidence examining the effect of probiotics and derivatives added to maternal nutrition on infantile colic. Material and Methods: A comprehensive, systematic search of PubMed, Web of Science, the Cochrane Library, CINAHL and ULAKBİM databases was completed. In the systematic review, we examined the evidence about probiotics that could potentially be included. Contrary to what is usual, our review included maternal nutrition, but not infant feeding. Outcomes data including treatment success and crying times of infantile colic were collected to conduct an analysis. Meta-analysis of study outcomes was performed using Review Manager. The Grades of Recommendation, Assessment, Development and Evaluation Working Group (GRADE) approach was used to assess the quality of the body of evidence for each outcome of this meta-analysis. PROSPERO; registration number CRD42020155237. Results: In the review, 4 studies (1,110 participants) were included. The agreement between the 2 researchers was excellent, with Cohen kappa scores [95% confidence interval (CI)]=0.95 (I0.88-1) for article selection and 0.97 (I0.92-1) for bias scoring. The end of the intervention did not find a significant difference in treatment success between the 2 groups [risk ratio (RR) 1.14; 95% CI (0.4, 2.71)]. In a sensitivity analysis using the fixed effect model, we found a significant difference in favor of probiotics [RR 0.92; 95% CI (0.60, 1.42)]. Conclusion: Research suggests that the addition of some probiotics in the diet of mothers is reasonable for the treatment of infantile colic. However, more research is needed.