Akademik Veri Yönetim Sistemi
ARCHIVES OF EPILEPSY, cilt.31, sa.2, ss.42-46, 2025 (ESCI)
Objective: Genetic Absence Epilepsy Rats from Strasbourg (GAERS) exhibit notable resistance to amygdala kindling-induced seizures compared to Wistar rats. However, the influence of sex difference on kindling resistance in GAERS remains unexplored. This study aims to evaluate whether male and female GAERS differ in their susceptibility to kindling. Methods: Three-to-4-month-old female (n=6) and male (n=6) GAERS and male Wistar rats as control (n=6) were implanted with a stimulation electrode stereotaxically into the basolateral amygdala and four recording electrodes on the cortex. After one-week recovery, animals were stimulated at the afterdischarge (AD) threshold twice a day for kindling until the maximum number of 15 stimulations or three consecutive stage 5 seizures according to Racine's scale. Stage and cumulative amygdala AD duration were analysed using GraphPad Prism with a one-way ANOVA test. Results: At the end of the kindling procedure, all Wistar rats exhibited stage 5 seizures, whereas neither male nor female GAERS rats progressed to stage 5 (p<0.001). Cumulative amygdala AD duration was significantly higher in male Wistar rats compared to male GAERS (p=0.001) and female GAERS (p=0.01). However, no significant difference in cumulative amygdala AD duration was observed between male and female GAERS (p=0.94). Conclusion: We have confirmed that this resistance also applies to female GAERS. This finding implies the importance of studying sex differences in epilepsy, as most existing research has focused predominantly on males.