Akademik Veri Yönetim Sistemi
Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2025), Ankara, Türkiye, 25 - 27 Haziran 2025, ss.76, (Özet Bildiri)
Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like benzoquinone compound synthesized endogenously from tyrosine. Its potential health benefits have led to a growing consumer demand, making it the third most popular dietary supplement after multivitamins and fish oil [1]. However, the lack of standardized regulations in the production and labelling of dietary supplements raises concerns regarding product quality [2]. Since official market controls are infrequent, particularly for non-vitamin supplements, consumers are unable to verify the actual CoQ10 content, thereby increasing the risk of misleading practices. This study aimed to assess the accuracy of CoQ10 content labelling in dietary supplements available in the Turkish market. Ten CoQ10-containing supplements, in the form of soft gels, tablets, or sachets, were purchased from various sales channels, including pharmacies and non-pharmacy markets. The CoQ10 content was analysed using High-Performance Thin-Layer Chromatography (HPTLC) to determine compliance with the declared amounts. Results showed that within the generally accepted 90%-110% label compliance range, only 50% (5/10) of the samples met the label claims. One sample (10%) contained less CoQ10 than declared, while four (40%) exceeded the stated content. These findings indicate significant deviations in half of the analysed supplements, which could impact efficacy and safety. Given that CoQ10’s bioavailability depends on formulation and individual metabolism, deviations from the recommended dose may result in pharmacokinetic inconsistency and unexpected physiological effects. In conclusion, stricter quality control measures as well as regulatory oversight are necessary to ensure dietary supplements meet label claims. Regular inspections and standardized international guidelines should be implemented to enhance consumer safety and minimize inconsistencies in supplement content.