Olfactory function and olfactory bulb volume in Wilson's disease


DEĞİRMENCİ N., Veyseller B., Hanagasi H., Bilgic B., Gurbuz D., TOPRAK A., et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, cilt.276, ss.139-142, 2019 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 276 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s00405-018-5216-9
  • Dergi Adı: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Sayfa Sayısı: ss.139-142

Özet

PurposeTo evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson's Disease (WD) patients.MethodsA prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5T General Electric Signa Excite MRI scanner.ResultsThere was a significant difference between the CCCRC scores of the two groups (p<0.05). The difference of the OB volumes of the two groups was insignificant (p>0.05).ConclusionsWD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.