5-Flourouracil-Induced Encephalopathy in Parkinson's Disease

Korkmaz T., Seber S., BAŞARAN G., Yumuk P. F., Dane F., Kocar M., ...More

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, vol.22, no.1, pp.51-53, 2012 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.4999/uhod.10041
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.51-53
  • Keywords: Parkinson's disease, 5-Flourouracil, Rectum cancer, Encephalopathy, NEUROTOXICITY, 5-FLUOROURACIL, FLUOROURACIL, INFUSION
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


A 59 year-old male with Parkinson's disease developed encephalopathy during adjuvant treatment of rectal cancer. Acute neurotoxicity related to high dose 5-Flourouracil infusion is well described, but encephalopathy with low dose bolus 5-Flourouracil is rare. The advanced Parkinson's disease patients may be more prone to hyperammonemia associated encephalopathy caused by 5-Flourouracil. The prompt recognition of the symptoms is key to diagnosis and treatment.