5-Flourouracil-Induced Encephalopathy in Parkinson's Disease

Korkmaz T., Seber S., BAŞARAN G., Yumuk P. F., Dane F., Kocar M., ...Daha Fazla

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, cilt.22, sa.1, ss.51-53, 2012 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.4999/uhod.10041
  • Dergi Adı: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.51-53
  • Anahtar Kelimeler: Parkinson's disease, 5-Flourouracil, Rectum cancer, Encephalopathy, NEUROTOXICITY, 5-FLUOROURACIL, FLUOROURACIL, INFUSION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

A 59 year-old male with Parkinson's disease developed encephalopathy during adjuvant treatment of rectal cancer. Acute neurotoxicity related to high dose 5-Flourouracil infusion is well described, but encephalopathy with low dose bolus 5-Flourouracil is rare. The advanced Parkinson's disease patients may be more prone to hyperammonemia associated encephalopathy caused by 5-Flourouracil. The prompt recognition of the symptoms is key to diagnosis and treatment.