Local renin-angiotensin system in normal hematopoietic and multiple myeloma-related progenitor cells Normal hematopoetik ve multipl myelom i̇lişkili progenitor hücrelerde lokal renin-anjiotensin sistemi


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Uz B., Tatonyan S. C. , Sayitoglu M., Erbilgin Y., Hatirnaz Ö. , AKSU S., et al.

Turkish Journal of Hematology, cilt.31, ss.136-142, 2014 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 31 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.4274/tjh.2013.0011
  • Dergi Adı: Turkish Journal of Hematology
  • Sayfa Sayısı: ss.136-142

Özet

Objective: The prominent functions of the local renin-angiotensin system (RAS) in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis. The aim of this study is to examine critical RAS elements in normal CD34+ hematopoietic stem cells and multiple myeloma (MM)-related progenitor cells.