Dendritic, Water-Soluble, and Nonaggregated Axially Substituted Silicon Phthalocyanine as Potential Endometrial Anticancer Agent

KELEŞ T., SEYHAN G., BIYIKLIOĞLU Z., Kolci K., REIS R., BARUT B.

APPLIED ORGANOMETALLIC CHEMISTRY, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1002/aoc.7699
  • Dergi Adı: APPLIED ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Metadex, DIALNET, Civil Engineering Abstracts
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

In this work, dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanines (EA-TD-Si and EA-TD-SiQ) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of EA-TD-Si and EA-TD-SiQ were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of EA-TD-Si and EA-TD-SiQ on human endometrium adenocarcinoma (HEC-1B) cells were investigated using an MTT assay. The results indicated that EA-TD-SiQ had high photodamage properties via singlet oxygen depending on the light dose, while EA-TD-Si did not show any DNA damage without light. In addition, EA-TD-SiQ had higher phototoxic effects than EA-TD-Si on HEC-1B cells according to the MTT assay. These results revealed the potential of EA-TD-SiQ to be used as a PDT agent in endometrial cancer. We have synthesized dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanines. The supercoiled pBR322 plasmid DNA damage properties of EA-TD-Si and EA-TD-SiQ were examined using agarose gel electrophoresis without light irradiation. The cytotoxicity and phototoxicity of both compounds on human endometrium adenocarcinoma (HEC-1B) cells were investigated using an MTT assay.image