Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia


Altiok O., Yasumatsu R., Bingol-Karakoc G. , Riese R., Stahlman M., Dwyer W., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.173, no.3, pp.318-326, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 173 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1164/rccm.200503-425oc
  • Title of Journal : AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Page Numbers: pp.318-326

Abstract

Rationale: Bronchopulmonary dysplasia (BPD) continues to be a major morbidity in preterm infants. The lung pathology in BIRD is characterized by impaired alveolar and capillary development. An imbalance between proteases and protease inhibitors in association with changes in lung elastic fibers has been implicated in the pathogenesis of BIRD.