Pancreatic ductal adenocarcinoma: The Vision of Heracles

Mota Reyes, Carmen; Goetz, Mara; Algül, Hana; Dogruoez, Alper; Falcomatà, Chiara; Gaida, Matthias; Görgülü, Kıvanç; Gültekin, Yetiş; Gürcinar, Ibrahim; Hasselluhn, Marie; Istvanffy, Rouzanna; Kalluri, Raghu; Kalluri, Valerie; Kiemen, Ashley; Kim, Pilhan; Lee, Sang-Won; Lesina, Marina; Yu, Peter; Maitra, Anirban; Müller, Clara; Müller, Sebastian; Nam, Dowoon; Olive, Kenneth; Pasca Di Magliano, Marina; Rad, Roland; Saur, Dieter; Vander Heiden, Matthew; Vormehr, Mathias; Wood, Laura; Yöndem, Eyüp; Zschäpitz, David; Karakas, DİDEM; Friess, Helmut; Ceyhan, Güralp; Demir, Ihsan

doi:10.1016/j.ccell.2026.07.014

Pancreatic ductal adenocarcinoma: The Vision of Heracles

Mota Reyes C., Goetz M. R., Algül H., Dogruoez A., Falcomatà C., Gaida M. M., ...Daha Fazla

Cancer Cell, cilt.44, sa.9, ss.1721-1726, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Teknik Not
Cilt numarası: 44 Sayı: 9
Basım Tarihi: 2026
Doi Numarası: 10.1016/j.ccell.2026.07.014
Dergi Adı: Cancer Cell
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
Sayfa Sayıları: ss.1721-1726
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest malignancies, as tumors evolve faster than therapies. Resistance is ecological, not merely KRAS driven, involving overlooked players like high-grade pancreatic intraepithelial neoplasias (PanINs), peripancreatic fat, stromal mechanics, myeloid-neural circuits, metabolic rewiring, and systemic host responses. We propose precision interception targeting PanIN/intraductal papillary mucinous neoplasm (IPMN) biology, spatial-functional-proteogenomic classification beyond transcriptomics, the Heracles Protocol (measure, prime, strike, and adapt), and integrated technologies from AI pathology to exosomal delivery and CRISPR-based synergy mapping, together making PDAC more tractable.