Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate


Tuncel S., Fournier-dit-Chabert J., Albrieux F., Ahsen V., Ducki S., DUMOULIN F.

ORGANIC & BIOMOLECULAR CHEMISTRY, cilt.10, ss.1154-1157, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 10 Konu: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1039/c2ob06809e
  • Dergi Adı: ORGANIC & BIOMOLECULAR CHEMISTRY
  • Sayfa Sayıları: ss.1154-1157

Özet

A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(II) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.