Double bond configuration of palmitoleate is critical for atheroprotection

Cimen I., Yildirim Z., Dogan A. E., Yildirim A. D., Tufanli O., Onat U. İ., ...Daha Fazla

MOLECULAR METABOLISM, cilt.28, ss.58-72, 2019 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.molmet.2019.08.004
  • Dergi Adı: MOLECULAR METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.58-72
  • Anahtar Kelimeler: Lipid-induced inflammation, Lipokines, Palmitoleate, Ruminant trans-fatty acids, Organelle stress, Inflammasome, Atherosclerosis, TRANS-FATTY-ACIDS, ENDOPLASMIC-RETICULUM STRESS, UNFOLDED PROTEIN RESPONSE, NLRP3 INFLAMMASOME, DAIRY FAT, ER STRESS, EXPERIMENTAL ATHEROSCLEROSIS, UNSATURATED FATS, ADIPOSE-TISSUE, RISK
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective: Saturated and trans fat consumption is associated with increased cardiovascular disease (CVD) risk. Current dietary guidelines recommend low fat and significantly reduced trans fat intake. Full fat dairy can worsen dyslipidemia, but recent epidemiological studies show full-fat dairy consumption may reduce diabetes and CVD risk. This dairy paradox prompted a reassessment of the dietary guidelines. The beneficial metabolic effects in dairy have been claimed for a ruminant-derived, trans fatty acid, trans-C16: 1n-7 or trans-palmitoleate (trans-PAO). A close relative, cis-PAO, is produced by de novo lipogenesis and mediates inter-organ crosstalk, improving insulin-sensitivity and alleviating atherosclerosis in mice. These findings suggest trans-PAO may be a useful substitute for full fat dairy, but a metabolic function for trans-PAO has not been shown to date.