Assessment of p21, p53 expression, and Ki-67 proliferative activities in the gastric mucosa of children with Helicobacter pylori gastritis

Saf C., Gulcan E. M., ÖZKAN F., Saf S. P. C., Vitrinel A.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.27, no.2, pp.155-161, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1097/meg.0000000000000246
  • Journal Name: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.155-161
  • Keywords: gastric atrophy, gastritis, Helicobacter pylori, intestinal metaplasia, Ki-67, p21, p53, INTESTINAL METAPLASIA, PRECANCEROUS PROCESS, INFECTION, POPULATION, CARCINOMA, CLASSIFICATION, EPIDEMIOLOGY, PREVALENCE, CANCERS, SAMPLE
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background Helicobacter pylori that is generally acquired in childhood and infects the gastric mucosa is considered to be responsible for many pathobiological changes that are linked to the pathogenesis of gastric cancer. Although the majority of studies on the subject have been carried out in adults, there are a limited number of studies on children that reflect the early period of infection and may be of greater significance.