Encapsulation of photosensitising phthalocyanines into poly(malic acid) based nanoparticles: structural and experimental effects

Emamı A., Özdemir B., Harmandar K., İşçi Ü., Cammas-Marion S., Dumoulin F., ...Daha Fazla

19th Asian Chemical Congress, İstanbul, Türkiye, 9 - 14 Temmuz 2023, ss.160-161, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.160-161
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Encapsulation of Photosensitising Phthalocyanines into Poly(Malic Acid) Based Nanoparticles: Structural and Experimental Effects

Atefeh Emami1, Burak Özdemir1, Kevser Harmandar2, Devrim Atilla3, Ümit Işçi3, Sandrine Cammas Marion4, Fabienne Dumoulin5 , Emel Önal6


Phthalocyanines (Pcs) are among the most effective photosensi-tisers for photodynamic therapy, mainly due to their strong ab-sorption in the phototherapeutic window [1-2]. Most of them are hydrophobic, resulting in self-aggregation in aqueous media, which lowers their photodynamic efficiency. To overcome this obstacle, the encapsulation of Pcs into polymeric nanoparticles (NPs) to enhance their photophysico-chemical properties and solubility in water, as well as disrupt their aggregation is a good strategy [3]. Poly(malic acid) (PMLA) and its derivatives are good polymeric nanomaterials prepared via anionic ring-opening polymerization of benzyl malolactonate (MLABe). Two derivatives of PMLA, poly(benzyl malate) (PMLABe73) as a lipophilic polymer, and poly(ethylene glycol)-b-poly(benzyl malate) (PEG42-b-PMLABe73) as an amphiphilic block copolymer have been selected. To achieve tumor-targeting, biotin-functionalized Biot-PMLABe73 and Biot-PEG42-b-PMLABe73 were also prepared [4-5]. Three hydrophobic Pcs metalated with Zn or Pd and with either linear or bulky substituents (PdPc-OHex, ZnPc-OHex, and PdPc-OEtHex) were encapsulated into the hy-drophobic polymeric core with systematic variations of the encapsulation conditions.

The Scientific and Technological Research Council of Türkiye (TUBITAK) and the French Embassy in Türkiye are gratefully acknowledged for the bilateral Partenariat Hubert Curien

between Türkiye and France (project Bosphorus 120N684/4665SH).

References:

[1] P.-C. Lo, M. S. Rodríguez-Morgade, R. K. Pandey, D. K. P. Ng, T.Torres and F. Dumoulin, Chem. Soc. Rev. 2020, 49, 1041-1056.

[2] Z. S. Topal, Ü. İşci, U. Kumru, D. Atilla, A. G. Gürek, C. Hirel, M.Durmuş, J-B Tommasino, D. Luneau, S. Berber, F. Dumoulin and V. Ahsen, Dalton Trans. 2014, 43, 6897-6908.

[3] W. Borzęcka, A. Domiński, and M. Kowalczuk, Nanomaterials 2021, 11, 2426.

[4] Z. W. Huang, V. Laurent, G. Chetouani, J. Y. Ljubimova, E. Holler, T. Benvegnu, P. Loyer and S. Cammas-Marion, Int. J. Pharm. 2012, 423, 84-92.

[5] P. Loyer and S. Cammas-Marion, J. Drug Target., 2014, 22, 556-575.

Keywords: Phthalocyanines, Photosensitisers, Polymeric nanoparticles, Encapsulation.