Correlation of anatomical involvement patterns of insular gliomas with subnetworks of the limbic system

Ulgen E., Aras F. K., Cosgun E., Ersen-Danyeli A., DİNÇER A., USSELİ M. İ., ...Daha Fazla

JOURNAL OF NEUROSURGERY, cilt.136, sa.2, ss.323-334, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 136 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3171/2020.12.jns203652
  • Dergi Adı: JOURNAL OF NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.323-334
  • Anahtar Kelimeler: insula, hippocampus, limbic system, insular glioma, molecular subset, survival analysis, oncology, PROMOTER MUTATIONS, RESECTION, INVASION, TUMORS, CLASSIFICATION, PATHOLOGY, IDH
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

OBJECTIVE Gliomas frequently involve the insula both primarily and secondarily by invasion. Despite the high connectivity of the human insula, gliomas do not spread randomly to or from the insula but follow stereotypical anatomical involvement patterns. In the majority of cases, these patterns correspond to the intrinsic connectivity of the limbic system, except for tumors with aggressive biology. On the basis of these observations, the authors hypothesized that these different involvement patterns may be correlated with distinct outcomes and analyzed these correlations in an institutional cohort.